Aprovel 300 mg

Irbesartan 300 mg

Mechanism of Action
Angiotensin II receptor blocker; inhibits vasoconstrictor and aldosterone-secreting effects of angiotensin II

Bioavailability: 60-80%
Onset: 1-2 hr (peak effect)
Duration: 24 hr
Peak plasma time: 1.5-2 hr

Protein bound: 90%
Vd: 53-93 L

Metabolized by hepatic CYP2C9 and minimally by CYP3A4
Metabolites: Irbesartan glucuronide conjugate (inactive)

Half-life: 11-15 hr
Renal clearance: 3-3.5 mL/min
Total body clearance: 157-176 mL/min
Excretion: Feces (80%), urine (20%)

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Aprovel 300 mg only for the indication prescribed.