Aprovel 300 mg

Irbesartan 300 mg

Black Box Warnings
Discontinue as soon as possible when pregnancy is detected; drug affects renin-angiotensin system, causing oligohydramnios, which may result in fetal injury or death

Do not coadminister with aliskiren in patients with diabetes

Angioedema, volume-depletion, severe congestive heart failure (CHF), hepatic or renal impairment, hypertrophic cardiomyopathy, aortic or mitral valve stenosis, surgery or anesthesia
Discontinue immediately if patient is pregnant; risk of congenital malformations (see Contraindications and Black Box Warnings)
Use with caution in renal artery stenosis; avoid in bilateral renal artery stenosis
Risk of hypotension or hyperkalemia
Dual blockade of the renin-angiotensin system with ARBs, angiotensin-converting enzyme (ACE) inhibitors, or aliskiren is associated with increased risk of hypotension, hyperkalemia, and altered renal function (including acute renal failure) in comparison with monotherapy
Risk of heart failure-related morbidity; concomitant treatment with ACE inhibitors and beta-adrenergic agents is not recommended

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Aprovel 300 mg only for the indication prescribed.