Dafinace 5mg

Haloperidol 5mg

Pharmacology
Mechanism of Action
Phenylbutylpiperadine; antagonizes dopamine D1 and D2 receptors in brain; depresses reticular activating system and inhibits release of hypothalamic and hypophyseal hormones

Absorption
Bioavailability: 60-70%
Onset: 30-60 min (IM/IV)
Duration: 2-4 weeks (decanoate)
Peak plasma time: 2-6 hr (PO); 10-20 minutes(IM); 6-7 days (decanoate)

Distribution
Protein bound: 90%
Vd: 8-18 L/kg

Metabolism
Metabolized by hepatic P450 enzyme CYP3A4
Metabolites: Hydroxyhaloperidol
Enzymes inhibited: CYP2D6

Elimination
Half-life: 18 hr; 3 weeks (decanoate)
Excretion: Urine (30%), feces (15%)

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Dafinace 5mg only for the indication prescribed.