Detronin 5mg/5ml

Oxybutynin 5mg

Pharmacology
Mechanism of Action
Exerts antispasmodic and antimuscarinic effects on smooth muscle; delays desire to void, increases bladder capacity, and decreases uninhibited contraction; decreases frequency and urgency

Absorption
Bioavailability: 6% (~1.5-2 times higher for extended-release)
Onset: 30-60 min
Peak effect: 3-6 hr
Duration: 6-10 hr
Peak plasma time: <1 hr (immediate-release); 12 hr (extended release)
Peak plasma concentration: Immediate-release, 3.6 ng/mL (R-) and 7.8 ng/mL (S-); extended-release, 1 ng/mL (R-) and 1.8 ng/mL (S-)

Distribution
Vd: 193 L

Metabolism
Metabolized in liver and gut by CYP3A4; converted to active metabolite N-desethyloxybutynin (DEO) by GI metabolic pathways, which are bypassed in transdermal delivery, resulting in lower DEO ratio
Metabolites: DEO (active)

Elimination
Half-life: 2-3 hr (immediate-release); 12-13 hr (extended-release)
Excretion: Urine

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Detronin 5mg/5ml only for the indication prescribed.