Diarol 1mg

Repaglinide 1mg

Dosing & Uses
Adult

Dosage Forms & Strengths

tablet

  • 0.5 mg
  • 1 mg
  • 2 mg

Type 2 Diabetes Mellitus

Adjunct to diet and exercise

Initial: 0.5 mg PO with no prior treatment, OR 1-2 mg with prior treatment

Titrate by up to 4 mg; double preprandial dose until satisfactory blood glucose response attained; not to exceed 16 mg qDay

Administration

Take dose 15 minutes before meal; no more than 4 meals/day

Dosing Modifications

Renal impairment

  • CrCl 40-80 mL/min: No adjustments necessary
  • CrCl 20-40 mL/min: 0.5 mg with meals; titrate slowly and monitor
  • CrCl <20 mL/min: Data not available

Hepatic impairment

  • Use conservative initial and maintenance dosing; wait for longer intervals to make dosage adjustments

Dosing Considerations

Combination therapy

  • If monotherapy does not result in adequate glycemic control, may add metformin or thiazolidinedione
  • If thiazolidinedione and metformin do not result in adequate glycemic control, repaglinide may be added
  • Starting dose and dose adjustments for combination therapy are the same as those for repaglinide monotherapy

Pediatric

Safety and efficacy not established

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Diarol 1mg only for the indication prescribed.