Diarol 1mg

Repaglinide 1mg

Pharmacology
Mechanism of Action
Increases insulin secretion by blocking ATP potassium channels on beta islet cells, which facilitates calcium entry through calcium channels; increased intracellular calcium stimulates insulin release from pancreatic beta cells

Absorption
Bioavailability: 56%
Onset: 15-60 min (increased insulin levels)
Duration: 4-6 hr
Peak plasma time: 1 hr

Distribution
Protein bound: >98%
Vd: 31 L

Metabolism
Metabolized extensively in liver, by CYP3A4 and CYP2C8
Metabolites: Oxidized dicarboxylic acid, aromatic amine, acyl glucuronide (inactive)

Elimination
Half-life: 1 hr
Total body clearance: 38 L/hr
Excretion: Feces (90%); urine (8%)

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Diarol 1mg only for the indication prescribed.