Diusex 20mg/2ml

Furosemide 20mg

Pharmacology
Mechanism of Action
Loop diuretic; inhibits reabsorption of sodium and chloride ions at proximal and distal renal tubules and loop of Henle; by interfering with chloride-binding cotransport system, causes increases in water, calcium, magnesium, sodium, and chloride

Absorption
Bioavailability: 47-64% (PO)
Onset: 30-60 min (PO/SL); 30 min (IM); 5 min (IV)
Peak effect: <15 min (IV); 1-2 hr (PO/SL)
Duration: 2 hr (IV); 6-8 hr (PO)

Distribution
Protein bound: 91-99%
Vd: 0.2 L/kg

Metabolism
Metabolized in liver (~10%)
Metabolite: Glucuronide (2-amino-4-chloro-5-sulfamoylanthranilic acid [saluamine]) (activity unknown)

Elimination
Half-life: 30-120 min (normal renal function); 9 hr (end-stage renal disease)
Dialyzable: No
Renal clearance: 2 mL/min/kg
Excretion: Urine (PO, 50%; IV, 80%)

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Diusex 20mg/2ml only for the indication prescribed.