Dosin

Doxazosin

Dosing & Uses
Adult

Dosage Forms & Strengths

tablet

  • 1 mg
  • 2 mg
  • 4 mg
  • 8 mg

tablet, extended release

  • 4 mg
  • 8 mg

Hypertension

1 mg PO qDay in AM or PM; may titrate by doubling daily dose up to 16 mg qDay based on blood pressure response; usual dosage range is 1-2 mg qDay; if therapy is discontinued for several days, initiate dose at 1 mg qDay and titrate using initial dosing regimen

Extended release: Not indicated for hypertension

Benign Prostatic Hyperplasia

Immediate release: 1 mg PO qDay; may titrate by doubling daily dose at 1-2 week intervals to maximum 8 mg/day

If therapy is discontinued for several days, initiate dose at 1 mg qDay and titrate using initial dosing regimen

Extended release: 4 mg PO qDay; may titrate based on response and tolerability every 3-4 weeks to 8 mg PO qDay

If therapy is discontinued for several days, initiate dose at 1 mg qDay and titrate using initial dosing regimen

Dosing Modifications

Hepatic impairment: Use with caution in mild-to-moderate hepatic dysfunction; do not use in severe impairment

Renal impairment: Labeling from manufacturer does not provide dosage adjustment information

Dosing Considerations

Give first dose and increase at bedtime to avoid syncope

Pediatric

Dosage Forms & Strengths

tablet

  • 1 mg
  • 2 mg
  • 4 mg
  • 8 mg

Hypertension (Off-label)

Immediate release: 1-4 mg PO once daily in AM or PM

Geriatric

Hypertension

Avoid use for hypertension; high risk of orthostatic hypotension (Beers criteria); if used, lower initial dosages and gradual adjustments are recommended

Immediate release: 0.5-16 mg PO once daily in AM or PM

Extended release: Not indicated for hypertension

Benign Prostatic Hyperplasia

Immediate release: 1-8 mg/day PO

Extended release: 4 mg/day PO initially at breakfast; may be increased to no more than 8 mg/day PO

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Dosin only for the indication prescribed.