Epinephrine 0.25mg/1ml

Epinephrine 0.25mg

Interactions
Contraindicated
  • astemizole: epinephrine and astemizole both increase QTc interval. Contraindicated.
  • cisapride: epinephrine and cisapride both increase QTc interval. Contraindicated.
  • disopyramide: epinephrine and disopyramide both increase QTc interval. Contraindicated.
  • ibutilide: epinephrine and ibutilide both increase QTc interval. Contraindicated.
  • indapamide: epinephrine and indapamide both increase QTc interval. Contraindicated.
  • iobenguane i 123: epinephrine decreases effects of iobenguane i 123 by receptor binding competition. Contraindicated. If clinically appropriate, discontinue drugs that compete for NE receptor sites for at least 5 half-lives; may cause false-negative imaging results.
  • isocarboxazid: isocarboxazid increases effects of epinephrine by pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.
  • linezolid: linezolid increases effects of epinephrine by pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.
  • lurasidone: epinephrine increases toxicity of lurasidone by pharmacodynamic synergism. Contraindicated. Interaction applies only in setting of acute lurasidone overdose. Epinephrine may enhance hypotensive effects of lurasidone in overdose setting.
  • pentamidine: epinephrine and pentamidine both increase QTc interval. Contraindicated.
  • phenelzine: phenelzine increases effects of epinephrine by pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.
  • pimozide: epinephrine and pimozide both increase QTc interval. Contraindicated.
  • procainamide: epinephrine and procainamide both increase QTc interval. Contraindicated.
  • quinidine: epinephrine and quinidine both increase QTc interval. Contraindicated.
  • selegiline transdermal: selegiline transdermal increases effects of epinephrine by pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.
  • sotalol: epinephrine and sotalol both increase QTc interval. Contraindicated.
  • terfenadine: epinephrine and terfenadine both increase QTc interval. Contraindicated.
  • tranylcypromine: tranylcypromine increases effects of epinephrine by pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.
Serious - Use Alternative
  • amiodarone: epinephrine and amiodarone both increase QTc interval. Avoid or Use Alternate Drug.
  • amisulpride: epinephrine and amisulpride both increase QTc interval. Avoid or Use Alternate Drug.
  • amitriptyline: epinephrine and amitriptyline both increase QTc interval. Avoid or Use Alternate Drug.
    amitriptyline, epinephrine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.
  • amoxapine: epinephrine and amoxapine both increase QTc interval. Avoid or Use Alternate Drug.
    amoxapine, epinephrine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.
  • artemether/lumefantrine: epinephrine and artemether/lumefantrine both increase QTc interval. Avoid or Use Alternate Drug.
  • cabergoline: cabergoline, epinephrine. Mechanism: pharmacodynamic synergism. Contraindicated. Additive vasospasm; risk of hypertension.
  • chlorpromazine: epinephrine and chlorpromazine both increase QTc interval. Avoid or Use Alternate Drug.
  • clarithromycin: epinephrine and clarithromycin both increase QTc interval. Avoid or Use Alternate Drug.
  • clomipramine: epinephrine and clomipramine both increase QTc interval. Avoid or Use Alternate Drug.
    clomipramine, epinephrine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.
  • desflurane: desflurane increases toxicity of epinephrine by Mechanism: unknown. Avoid or Use Alternate Drug. Risk of V tach, HTN.
    desflurane increases levels of epinephrine by decreasing metabolism. Contraindicated.
  • desipramine: epinephrine and desipramine both increase QTc interval. Avoid or Use Alternate Drug.
    desipramine, epinephrine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.
  • dihydroergotamine: dihydroergotamine, epinephrine. Mechanism: pharmacodynamic synergism. Contraindicated. Additive vasospasm; risk of hypertension.
  • dihydroergotamine intranasal: dihydroergotamine intranasal, epinephrine. Mechanism: pharmacodynamic synergism. Contraindicated. Additive vasospasm; risk of hypertension.
  • dofetilide: epinephrine and dofetilide both increase QTc interval. Avoid or Use Alternate Drug.
  • dosulepin: epinephrine and dosulepin both increase QTc interval. Avoid or Use Alternate Drug.
    dosulepin, epinephrine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.
  • doxapram: doxapram increases effects of epinephrine by pharmacodynamic synergism. Avoid or Use Alternate Drug. Additive pressor effect.
  • doxepin: epinephrine and doxepin both increase QTc interval. Avoid or Use Alternate Drug.
    doxepin, epinephrine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.
  • dronedarone: epinephrine and dronedarone both increase QTc interval. Avoid or Use Alternate Drug.
  • droperidol: epinephrine and droperidol both increase QTc interval. Avoid or Use Alternate Drug.
  • enflurane: enflurane increases toxicity of epinephrine by Mechanism: unknown. Avoid or Use Alternate Drug. Risk of V tach, HTN.
    enflurane increases levels of epinephrine by decreasing metabolism. Contraindicated.
  • ergoloid mesylates: ergoloid mesylates, epinephrine. Mechanism: pharmacodynamic synergism. Contraindicated. Additive vasospasm; risk of hypertension.
  • ergonovine: ergonovine, epinephrine. Mechanism: pharmacodynamic synergism. Contraindicated. Additive vasospasm; risk of hypertension.
  • ergotamine: ergotamine, epinephrine. Mechanism: pharmacodynamic synergism. Contraindicated. Additive vasospasm; risk of hypertension.
  • erythromycin base: epinephrine and erythromycin base both increase QTc interval. Avoid or Use Alternate Drug.
  • erythromycin ethylsuccinate: epinephrine and erythromycin ethylsuccinate both increase QTc interval. Avoid or Use Alternate Drug.
  • erythromycin lactobionate: epinephrine and erythromycin lactobionate both increase QTc interval. Avoid or Use Alternate Drug.
  • erythromycin stearate: epinephrine and erythromycin stearate both increase QTc interval. Avoid or Use Alternate Drug.
  • ether: ether increases toxicity of epinephrine by Mechanism: unknown. Avoid or Use Alternate Drug. Risk of V tach, HTN.
  • etomidate: etomidate increases levels of epinephrine by decreasing metabolism. Contraindicated.
  • fluconazole: epinephrine and fluconazole both increase QTc interval. Avoid or Use Alternate Drug.
  • fluphenazine: epinephrine and fluphenazine both increase QTc interval. Avoid or Use Alternate Drug.
  • formoterol: epinephrine and formoterol both increase QTc interval. Avoid or Use Alternate Drug.
  • haloperidol: epinephrine and haloperidol both increase QTc interval. Avoid or Use Alternate Drug.
  • imipramine: epinephrine and imipramine both increase QTc interval. Avoid or Use Alternate Drug.
    imipramine, epinephrine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.
  • isoflurane: isoflurane increases toxicity of epinephrine by Mechanism: unknown. Avoid or Use Alternate Drug. Risk of V tach, HTN.
  • itraconazole: epinephrine and itraconazole both increase QTc interval. Avoid or Use Alternate Drug.
  • ketamine: ketamine increases levels of epinephrine by unknown mechanism. Avoid or Use Alternate Drug.
  • ketoconazole: epinephrine and ketoconazole both increase QTc interval. Avoid or Use Alternate Drug.
  • levomilnacipran: levomilnacipran increases levels of epinephrine by pharmacodynamic synergism. Avoid or Use Alternate Drug. Risk of paroxysmal HTN, arrhythmia.
  • lofepramine: epinephrine and lofepramine both increase QTc interval. Avoid or Use Alternate Drug.
    lofepramine, epinephrine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.
  • lumefantrine: epinephrine and lumefantrine both increase QTc interval. Avoid or Use Alternate Drug.
  • maprotiline: epinephrine and maprotiline both increase QTc interval. Avoid or Use Alternate Drug.
    maprotiline, epinephrine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.
  • methoxyflurane: methoxyflurane increases toxicity of epinephrine by Mechanism: unknown. Avoid or Use Alternate Drug. Risk of V tach, HTN.
  • methylergonovine: methylergonovine, epinephrine. Mechanism: pharmacodynamic synergism. Contraindicated. Additive vasospasm; risk of hypertension.
  • mianserin: epinephrine and mianserin both increase QTc interval. Avoid or Use Alternate Drug.
    mianserin, epinephrine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.
  • milnacipran: milnacipran increases levels of epinephrine by pharmacodynamic synergism. Avoid or Use Alternate Drug. Risk of paroxysmal HTN, arrhythmia.
  • moxifloxacin: epinephrine and moxifloxacin both increase QTc interval. Avoid or Use Alternate Drug.
  • nadolol: nadolol increases effects of epinephrine by pharmacodynamic synergism. Avoid or Use Alternate Drug. Risk of hypertension and bradycardia. Consider selective beta 1 blocker (e.g., metoprolol).
  • nortriptyline: epinephrine and nortriptyline both increase QTc interval. Avoid or Use Alternate Drug.
    nortriptyline, epinephrine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.
  • octreotide: epinephrine and octreotide both increase QTc interval. Avoid or Use Alternate Drug.
  • octreotide (antidote): epinephrine and octreotide (antidote) both increase QTc interval. Avoid or Use Alternate Drug.
  • perphenazine: epinephrine and perphenazine both increase QTc interval. Avoid or Use Alternate Drug.
  • pindolol: pindolol increases effects of epinephrine by pharmacodynamic synergism. Avoid or Use Alternate Drug. Risk of hypertension and bradycardia. Consider selective beta 1 blocker (e.g., metoprolol).
  • procarbazine: procarbazine increases effects of epinephrine by pharmacodynamic synergism. Avoid or Use Alternate Drug. Risk of acute hypertensive episode.
  • prochlorperazine: epinephrine and prochlorperazine both increase QTc interval. Avoid or Use Alternate Drug.
  • promazine: epinephrine and promazine both increase QTc interval. Avoid or Use Alternate Drug.
  • promethazine: epinephrine and promethazine both increase QTc interval. Avoid or Use Alternate Drug.
  • propofol: propofol increases levels of epinephrine by unknown mechanism. Avoid or Use Alternate Drug.
  • propranolol: propranolol increases effects of epinephrine by pharmacodynamic synergism. Avoid or Use Alternate Drug. Risk of hypertension and bradycardia. Consider selective beta 1 blocker (e.g., metoprolol).
  • protriptyline: epinephrine and protriptyline both increase QTc interval. Avoid or Use Alternate Drug.
    protriptyline, epinephrine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.
  • sertindole: epinephrine and sertindole both increase QTc interval. Avoid or Use Alternate Drug.
  • sevoflurane: sevoflurane increases toxicity of epinephrine by Mechanism: unknown. Avoid or Use Alternate Drug. Risk of V tach, HTN.
  • thioridazine: epinephrine and thioridazine both increase QTc interval. Avoid or Use Alternate Drug.
  • timolol: timolol increases effects of epinephrine by pharmacodynamic synergism. Avoid or Use Alternate Drug. Risk of hypertension and bradycardia. Consider selective beta 1 blocker (e.g., metoprolol).
  • trazodone: epinephrine and trazodone both increase QTc interval. Avoid or Use Alternate Drug.
    trazodone, epinephrine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.
  • trifluoperazine: epinephrine and trifluoperazine both increase QTc interval. Avoid or Use Alternate Drug.
  • trimipramine: epinephrine and trimipramine both increase QTc interval. Avoid or Use Alternate Drug.
    trimipramine, epinephrine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.
  • yohimbe: yohimbe, epinephrine. Mechanism: pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.
  • ziprasidone: epinephrine and ziprasidone both increase QTc interval. Avoid or Use Alternate Drug.
Monitor Closely
  • acebutolol: acebutolol increases and epinephrine decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.
    acebutolol decreases effects of epinephrine by pharmacodynamic antagonism. Use Caution/Monitor.
  • aceclofenac: aceclofenac increases and epinephrine decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  • acemetacin: acemetacin increases and epinephrine decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  • albuterol: albuterol and epinephrine both decrease serum potassium. Use Caution/Monitor.
    albuterol and epinephrine both decrease sedation. Use Caution/Monitor.
    albuterol and epinephrine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.
  • alfentanil: alfentanil increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  • alprazolam: alprazolam increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  • amiloride: amiloride increases and epinephrine decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.
  • amisulpride: amisulpride increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  • amitriptyline: amitriptyline increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
    amitriptyline increases effects of epinephrine by unknown mechanism. Use Caution/Monitor.
  • amobarbital: amobarbital increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  • amoxapine: amoxapine increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
    amoxapine increases effects of epinephrine by unknown mechanism. Use Caution/Monitor.
  • arformoterol: arformoterol and epinephrine both decrease serum potassium. Use Caution/Monitor.
    arformoterol and epinephrine both decrease sedation. Use Caution/Monitor.
    arformoterol and epinephrine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.
  • aripiprazole: aripiprazole increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  • armodafinil: epinephrine and armodafinil both decrease sedation. Use Caution/Monitor.
  • aspirin: aspirin increases and epinephrine decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  • aspirin rectal: aspirin rectal increases and epinephrine decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. .
  • aspirin/citric acid/sodium bicarbonate: aspirin/citric acid/sodium bicarbonate increases and epinephrine decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  • atenolol: atenolol increases and epinephrine decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.
    atenolol decreases effects of epinephrine by pharmacodynamic antagonism. Use Caution/Monitor.
  • atomoxetine: atomoxetine, epinephrine. Other (see comment). Use Caution/Monitor. Comment: Due to the potential for increases in blood pressure and heart rate, atomoxetine should be used cautiously with vasopressors such as epinephrine.
  • azelastine: azelastine increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  • azithromycin: epinephrine and azithromycin both increase QTc interval. Use Caution/Monitor.
  • bambuterol: bambuterol and epinephrine both decrease serum potassium. Use Caution/Monitor.
    bambuterol and epinephrine both decrease sedation. Use Caution/Monitor.
    bambuterol and epinephrine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.
  • belladonna and opium: belladonna and opium increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  • bendroflumethiazide: epinephrine and bendroflumethiazide both decrease serum potassium. Use Caution/Monitor.
  • benperidol: benperidol increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  • benzphetamine: epinephrine and benzphetamine both decrease sedation. Use Caution/Monitor.
    epinephrine and benzphetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.
  • betaxolol: betaxolol increases and epinephrine decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.
    betaxolol decreases effects of epinephrine by pharmacodynamic antagonism. Use Caution/Monitor.
  • bisoprolol: bisoprolol increases and epinephrine decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.
    bisoprolol decreases effects of epinephrine by pharmacodynamic antagonism. Use Caution/Monitor.
  • bromocriptine: bromocriptine, epinephrine. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Hypertension, V tach.
  • brompheniramine: brompheniramine increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  • bumetanide: epinephrine and bumetanide both decrease serum potassium. Use Caution/Monitor.
  • buprenorphine buccal: buprenorphine buccal increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  • butabarbital: butabarbital increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  • butalbital: butalbital increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  • butorphanol: butorphanol increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  • caffeine: epinephrine and caffeine both decrease sedation. Use Caution/Monitor.
  • carbenoxolone: epinephrine and carbenoxolone both decrease serum potassium. Use Caution/Monitor.
  • carbinoxamine: carbinoxamine increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  • carvedilol: carvedilol increases and epinephrine decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.
    carvedilol decreases effects of epinephrine by pharmacodynamic antagonism. Use Caution/Monitor.
  • celecoxib: celecoxib increases and epinephrine decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  • celiprolol: celiprolol increases and epinephrine decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.
    celiprolol decreases effects of epinephrine by pharmacodynamic antagonism. Use Caution/Monitor.
  • chloral hydrate: chloral hydrate increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  • chlordiazepoxide: chlordiazepoxide increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  • chlorothiazide: epinephrine and chlorothiazide both decrease serum potassium. Use Caution/Monitor.
  • chlorpheniramine: chlorpheniramine increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  • chlorpromazine: chlorpromazine increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
    chlorpromazine, epinephrine. Mechanism: unknown. Use Caution/Monitor. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Interaction more likely in certain predisposed pts. only.
    chlorpromazine decreases effects of epinephrine by pharmacodynamic antagonism. Use Caution/Monitor. Block pressor response to epinephrine, which may result in severe hypotension and tachycardia.
  • chlorthalidone: epinephrine and chlorthalidone both decrease serum potassium. Use Caution/Monitor.
  • choline magnesium trisalicylate: choline magnesium trisalicylate increases and epinephrine decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. .
  • cinnarizine: cinnarizine increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  • clemastine: clemastine increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  • clomethiazole: clomethiazole increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  • clomipramine: clomipramine increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
    clomipramine increases effects of epinephrine by unknown mechanism. Use Caution/Monitor.
  • clonazepam: clonazepam increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  • clorazepate: clorazepate increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  • clozapine: clozapine increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
    clozapine decreases effects of epinephrine by pharmacodynamic antagonism. Use Caution/Monitor. Block pressor response to epinephrine, which may result in severe hypotension and tachycardia.
  • codeine: codeine increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  • cyclizine: cyclizine increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  • cyclopenthiazide: epinephrine and cyclopenthiazide both decrease serum potassium. Use Caution/Monitor.
  • cyproheptadine: cyproheptadine increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  • deflazacort: epinephrine and deflazacort both decrease serum potassium. Use Caution/Monitor.
  • desipramine: desipramine increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
    desipramine increases effects of epinephrine by unknown mechanism. Use Caution/Monitor.
  • dexchlorpheniramine: dexchlorpheniramine increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  • dexfenfluramine: epinephrine and dexfenfluramine both decrease sedation. Use Caution/Monitor.
    epinephrine and dexfenfluramine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.
  • dexmedetomidine: dexmedetomidine increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  • dexmethylphenidate: epinephrine and dexmethylphenidate both decrease sedation. Use Caution/Monitor.
    epinephrine and dexmethylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.
  • dextroamphetamine: epinephrine and dextroamphetamine both decrease sedation. Use Caution/Monitor.
    epinephrine and dextroamphetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.
  • dextromoramide: dextromoramide increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  • diamorphine: diamorphine increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  • dichlorphenamide: dichlorphenamide and epinephrine both decrease serum potassium. Use Caution/Monitor.
    dichlorphenamide, epinephrine. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Both drugs can cause metabolic acidosis.
  • diclofenac: diclofenac increases and epinephrine decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  • diethylpropion: epinephrine and diethylpropion both decrease sedation. Use Caution/Monitor.
    epinephrine and diethylpropion both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.
  • difenoxin hcl: difenoxin hcl increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  • diflunisal: diflunisal increases and epinephrine decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  • digoxin: digoxin increases and epinephrine decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  • dimenhydrinate: dimenhydrinate increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  • diphenhydramine: diphenhydramine increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  • diphenoxylate hcl: diphenoxylate hcl increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  • dipipanone: dipipanone increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  • dobutamine: dobutamine and epinephrine both decrease serum potassium. Use Caution/Monitor.
    dobutamine and epinephrine both decrease sedation. Use Caution/Monitor.
    dobutamine and epinephrine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.
  • dolasetron: epinephrine and dolasetron both increase QTc interval. Modify Therapy/Monitor Closely.
  • dopamine: epinephrine and dopamine both decrease sedation. Use Caution/Monitor.
    epinephrine and dopamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.
  • dopexamine: dopexamine and epinephrine both decrease serum potassium. Use Caution/Monitor.
    dopexamine and epinephrine both decrease sedation. Use Caution/Monitor.
    dopexamine and epinephrine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.
    dopexamine, epinephrine. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor.
  • dosulepin: dosulepin increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
    dosulepin increases effects of epinephrine by unknown mechanism. Use Caution/Monitor.
  • doxepin: doxepin increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
    doxepin increases effects of epinephrine by unknown mechanism. Use Caution/Monitor.
  • droperidol: droperidol increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  • drospirenone: drospirenone increases and epinephrine decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.
  • droxidopa: epinephrine and droxidopa both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor. May increase risk for supine hypertension
  • enflurane: enflurane increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. .
  • entacapone: entacapone increases effects of epinephrine by pharmacodynamic synergism. Use Caution/Monitor.
  • ephedrine: ephedrine and epinephrine both decrease serum potassium. Use Caution/Monitor.
    ephedrine and epinephrine both decrease sedation. Use Caution/Monitor.
    ephedrine and epinephrine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.
    ephedrine, epinephrine. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor.
  • ephedrine (pulmonary): ephedrine (pulmonary) and epinephrine both decrease serum potassium. Use Caution/Monitor.
    ephedrine (pulmonary) and epinephrine both decrease sedation. Use Caution/Monitor.
    ephedrine (pulmonary) and epinephrine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.
    ephedrine (pulmonary), epinephrine. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor.
  • epinephrine racemic: epinephrine and epinephrine racemic both decrease serum potassium. Use Caution/Monitor.
    epinephrine and epinephrine racemic both decrease sedation. Use Caution/Monitor.
    epinephrine and epinephrine racemic both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.
    epinephrine, epinephrine racemic. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely.
  • esmolol: esmolol increases and epinephrine decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.
    esmolol decreases effects of epinephrine by pharmacodynamic antagonism. Use Caution/Monitor.
  • estazolam: estazolam increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  • ethacrynic acid: epinephrine and ethacrynic acid both decrease serum potassium. Use Caution/Monitor.
  • ethanol: ethanol increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  • etodolac: etodolac increases and epinephrine decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  • etoricoxib: etoricoxib increases and epinephrine decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  • fenbufen: fenbufen increases and epinephrine decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  • fenfluramine: epinephrine and fenfluramine both decrease sedation. Use Caution/Monitor.
    epinephrine and fenfluramine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.
  • fenoprofen: fenoprofen increases and epinephrine decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  • flecainide: epinephrine and flecainide both increase QTc interval. Modify Therapy/Monitor Closely.
  • fluoxetine: epinephrine and fluoxetine both increase QTc interval. Modify Therapy/Monitor Closely.
  • fluphenazine: fluphenazine increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
    fluphenazine, epinephrine. Mechanism: unknown. Use Caution/Monitor. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Interaction more likely in certain predisposed pts. only.
    fluphenazine decreases effects of epinephrine by pharmacodynamic antagonism. Use Caution/Monitor. Block pressor response to epinephrine, which may result in severe hypotension and tachycardia.
  • flurazepam: flurazepam increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  • flurbiprofen: flurbiprofen increases and epinephrine decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  • fluvoxamine: epinephrine and fluvoxamine both increase QTc interval. Modify Therapy/Monitor Closely.
  • formoterol: epinephrine and formoterol both decrease serum potassium. Use Caution/Monitor.
    epinephrine and formoterol both decrease sedation. Use Caution/Monitor.
    epinephrine and formoterol both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.
  • foscarnet: epinephrine and foscarnet both increase QTc interval. Modify Therapy/Monitor Closely.
  • furosemide: epinephrine and furosemide both decrease serum potassium. Use Caution/Monitor.
  • gentamicin: epinephrine and gentamicin both decrease serum potassium. Use Caution/Monitor.
  • green tea: green tea increases effects of epinephrine by pharmacodynamic synergism. Use Caution/Monitor. Due to caffeine content. Combination may increase CNS stimulatory effects due to caffeine in green tea.
  • haloperidol: haloperidol increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  • hexobarbital: hexobarbital increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  • hydralazine: hydralazine, epinephrine. Mechanism: pharmacodynamic antagonism. Use Caution/Monitor. Sympathomimetics can antagonize the activity of some antihypertensive agents.
  • hydrochlorothiazide: epinephrine and hydrochlorothiazide both decrease serum potassium. Use Caution/Monitor.
  • hydrocodone: hydrocodone increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  • hydromorphone: hydromorphone increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  • hydroxyzine: hydroxyzine increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  • ibuprofen: ibuprofen increases and epinephrine decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  • ibuprofen iv: ibuprofen iv increases and epinephrine decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  • iloperidone: epinephrine and iloperidone both increase QTc interval. Modify Therapy/Monitor Closely.
    iloperidone increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
  • imipramine: imipramine increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
    imipramine increases effects of epinephrine by unknown mechanism. Use Caution/Monitor.
  • indacaterol, inhaled: epinephrine increases effects of indacaterol, inhaled by Other (see comment). Use Caution/Monitor. Comment: If additional adrenergic drugs are to be administered by any route, they should be used with caution because the s

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Epinephrine 0.25mg/1ml only for the indication prescribed.