Glimaryl 2mg Tablet

Glimepiride 2mg

Pharmacology
Mechanism of Action
Initial effect to increase insulin secretion from beta cells; may also decrease rate of hepatic glucose production and increase insulin receptor sensitivity

Absorption
Bioavailability: 100%
Initial effect: 1 hr
Peak plasma time: 2-3 hr
Max effect: 2-4 hr
Duration: 24 hr

Distribution
Vd: 8.8 L
Protein bound: 99.5%

Metabolism
Metabolized extensively by hepatic P450 enzyme CYP2C9 to less-active metabolites
Metabolites: Cyclohexyl hydroxy methyl derivative (M1; mildly active) and the carboxyl derivative (M2; inactive)

Elimination
Half-life: 5-9 hr
Total body clearance: 47.8 mL/min
Excretion: Urine (60%); feces (40%)

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Glimaryl 2mg Tablet only for the indication prescribed.