Depofort b12 1000 mcg/1 ml

Vitamin b12 1 mg

Dosing & Uses
Adult

Dosage Forms & Strengths

tablet

  • 100 mcg
  • 250 mcg
  • 500 mcg
  • 1000 mcg

tablet, extended release

  • 1000 mcg

tablet, sublingual

  • 2500 mcg

injectable solution

  • 1000 mcg/mL

nasal spray

  • 500 mcg/spray

Nutritional Supplementation

Recommended daily allowance (RDA)

>19 years: 2.4 mcg

Pregnant women: 2.6 mcg

Breastfeeding women: 2.8 mcg

Dietary supplement: 50-6,000 mcg/day

Pernicious Anemia

Manufacturer recommendation: 100 mcg IM/SC once daily for 6-7 days, then every other day for 7 doses, then every 3-4 days for 2-3 weeks, then monthly

Alternative parenteral dosing: 1000 mcg IM/SC once daily for 7 days, then weekly for 1 month, then monthly

Nasal spray: 500 mcg (1 spray in 1 nostril) weekly; if patient is taking hot meals, spray should be administered 1 hour before or after meal

B12 Deficiency

Initial: 30 mcg IM once daily for 5-10 days

Maintenance: 100-200 mcg IM monthly

Nasal dose: 500 mcg once weekly

Dosing considerations

  • PO absorption requires intrinsic factor
  • Cyanide poisoning: See Hydroxycobalamin AD
Pediatric
Dosage Forms & Strengths
tablet

  • 100 mcg
  • 250 mcg
  • 500 mcg
  • 1000 mcg
tablet, extended release

  • 1000 mcg
tablet, sublingual

  • 2500 mcg
injectable solution

  • 1000 mcg/mL
nasal spray

  • 500 mcg/spray
Nutritional Supplementation
RDA
0-6 months: 0.4 mcg
7-12 months: 0.5 mcg
1-3 years: 0.9 mcg
4-8 years: 1.2 mcg
9-13 years: 1.8 mcg
>14 years: 2.4 mcg

Pernicious Anemia
30-50 mcg IM/SC once daily for &ge2 weeks for total dose of 1,000 mcg to 5,000 mcg administer concomitantly with 1 mg/day of folic acid for 1 month
Maintenance: 100 mcg IM/SC monthly

B12 Deficiency
0.2 mcg/kg for 2 days; follow by 1,000 mcg/day for 2-7 days; follow by 100 mcg/day for 2-7 days; then 100 mcg/week for 1 month
Maintenance: 100 mcg IM/SC monthly

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Depofort b12 1000 mcg/1 ml only for the indication prescribed.