Depofort b12 1000 mcg/1 ml

Vitamin b12 1 mg

Hypersensitivity to product; sensitivity to cobalt

Intensive treatment of B12-deficient megaloblastic anemia may cause hypokalemia and sudden death
Nasal disease; defer use until symptoms resolve
Use with caution in patients with Leber optic nerve atrophy
Injection is incompatible with some common drugs (eg, warfarin and several phenothiazines) but is compatible with vitamins B and C
Vitamin B12 deficiency for >3 months results in irreversible degenerative CNS lesions
Thrombocytosis may occur with treatment of severe vitamin B12 megaloblastic anemia
Oral and intranasal route are not indicated for the treatment of pernicious anemia until symptoms resolve
Vitamin B12 deficiency masks signs of polycythemia vera; vitamin B12 administration may unmask condition
IM and SC route used to treat pernicious anemia; oral and intranasal not indicated until hematologic remission and no signs of nervous system involvement
Use with caution in patients with Leber’s disease; B12 treatment may result in rapid optic atrophy
Parenteral product may contain aluminum; toxic aluminum concentrations may occur with renal dysfunction, high doses, or prolonged use
Efficacy of intranasal administration in patients with nasal pathology or concomitant therapy has not been determined; use with caution

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Depofort b12 1000 mcg/1 ml only for the indication prescribed.