Ins. humulin n 100i.u/ml 1v 10ml

Insulin isophane 100 i.u.

Dosing & Uses
Adult

Dosage Forms & Strengths

insulin isophane human/insulin regular human

injectable suspension

  • (70 units/30 units)/mL

Type 1 Diabetes Mellitus

Suggested guidelines for beginning dose

Ketones moderate or less: 0.5 U/kg/day SC

Ketones large: 0.7 U/kg/day SC

Typically, 50-75% of total daily dose is given as intermediate- or long-acting insulin

May use this combination product if the dosage ratio of NPH (isophane) to regular is 2:1

Type 2 Diabetes Mellitus

Suggested guidelines for beginning dose; adjust according to blood glucose levels

Initial dose: 0.5-1 units/kg/day in divided doses

Typically, 50-75% of total daily dose is given as intermediate- or long-acting insulin

May use this combination product if the dosage ratio of NPH (isophane) to regular is 2:1

Morning

  • Give 2/3rds of daily insulin SC
  • Ratio of regular insulin to NPH (isophane) insulin 1:2

Evening

  • Give 1/3 of daily insulin SC

Administration

Administer within 15 min before a meal or immediately after a meal

Store unopened vials/pens refrigerated; do not freeze

Opened (in-use) product may be stored at ambient room temperature (below 86°F [30°C]) and away from heat and light

Dosage Adjustment Strategies

Dosage of human insulin, which is always expressed in USP units, must be based on the results of blood and urine glucose tests and must be carefully individualized to optimal effect

Dose adjustments should be based on regular blood glucose testing (See Dosage Adjustment Strategies)

Adjust to achieve appropriate glucose control

Look for consistent pattern in blood sugars for >3 days

  • Compare blood glucose for same time each day
  • For each time of day: calculate blood glucose range
  • Calculate median blood glucose
  • Consider eating and activity patterns during day

Adjust only one insulin dose at a time

  • Correct hypoglycemia first
  • Correct highest blood sugars next
  • If all blood sugars are high (within 2.75 mmol/L [50 mg/dL]): correct morning fasting blood glucose 1st
  • Many sliding scales exist to determine exact insulin dose based on frequent blood glucose monitoring
  • - Commonly written for q4hr blood glucose test
  • - Sliding scale coverage usually begins after blood glucose >11 mmol/L (200 mg/dL)
  • - If coverage is needed q4hr x 24 hr, then base insulin dose is adjusted first; sliding scale doses may be adjusted upwards as well
  • Change insulin doses in small increments
  • - Type I diabetes: 1-2 U change
  • - Type II diabetes: 2-3 U change

Pediatric

Dosage Forms & Strengths
insulin isophane human/insulin regular human
injectable suspension

  • (70 units/30 units)/mL
Type 1 Diabetes Mellitus
Suggested guidelines for beginning dose
Ketones moderate or less: 0.5 U/kg/day SC
Ketones large: 0.7 U/kg/day SC
Increased dose may be required during growth spurts
Typically, 50-75% of total daily dose is given as intermediate- or long-acting insulin
May use this combination product if the dosage ratio of NPH (isophane) to regular is 2:1

Administration
Administer within 15 min before a meal or immediately after a meal
Store unopened vials/pens refrigerated; do not freeze
Opened (in-use) product may be stored at ambient room temperature (below 86°F [30°C]) and away from heat and light

Dosage Adjustment Strategies
Dosage of human insulin, which is always expressed in USP units, must be based on the results of blood and urine glucose tests and must be carefully individualized to optimal effect
Dose adjustments should be based on regular blood glucose testing (See Dosage Adjustment Strategies)
Adjust to achieve appropriate glucose control
Look for consistent pattern in blood sugars for >3 days

  • Compare blood glucose for same time each day
  • For each time of day: calculate blood glucose range
  • Calculate median blood glucose
  • Consider eating and activity patterns during day
Adjust only one insulin dose at a time

  • Correct hypoglycemia first
  • Correct highest blood sugars next
  • If all blood sugars are high (within 2.75 mmol/L [50 mg/dL]): correct morning fasting blood glucose 1st
  • Many sliding scales exist to determine exact insulin dose based on frequent blood glucose monitoring
  • - Commonly written for q4hr blood glucose test
  • - Sliding scale coverage usually begins after blood glucose >11 mmol/L (200 mg/dL)
  • - If coverage is needed q4hr x 24 hr, then base insulin dose is adjusted first; sliding scale doses may be adjusted upwards as well
  • Change insulin doses in small increments; for type I diabetes - 1-2 U change

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Ins. humulin n 100i.u/ml 1v 10ml only for the indication prescribed.

Verified References
  • FDA Feb 10, 2018
  • CDC Feb 10, 2018
  • Mayo Clinic Feb 10, 2018
  • Drugs.com accessed Feb 10, 2018
  • Medscape accessed Feb 10, 2018
  • Epocrates accessed Feb 10, 2018
  • Webmd accessed Feb 10, 2018