Leukeran 5

Chlorambucil 5mg

Dosing & Uses
Adult

Dosage Forms & Strengths

tablet

  • 2 mg

Chronic Lymphatic (Lymphocytic) Leukemia

0.1 mg/kg/day for 3-6 weeks or  

0.4 mg/kg (increased by 0.1 mg/kg/dose until response/toxicity observed) biweekly or

0.4 mg/kg (increased by 0.1 mg/kg/dose until response observed) monthly or

0.03-0.1 mg/kg/day continuously

Reduce initial dose if administered within 4 weeks after a full course of radiation/myelosuppressive therapy or patients with bone marrow disease

Not to exceed 0.1 mg/kg/day if bone marrow infiltrated with lymphocytes

Hodgkin's Lymphoma

0.2 mg/kg/day for 3-6 weeks or  

0.4 mg/kg (increased by 0.1 mg/kg/dose until response/toxicity observed) biweekly or

0.4 mg/kg (increased by 0.1 mg/kg/dose until response or toxicity observed) monthly or

0.03-0.1 mg/kg/day continuously

Reduce initial dose if administered within 4 weeks after a full course of radiation/myelosuppressive therapy or patients with bone marrow diseas

Not to exceed 0.1 mg/kg/day if bone marrow infiltrated with lymphocytes

Renal Impairment

<1% (including metabolites) excreted in urine; no dose adjustment required

Hepatic Impairment

Primarily metabolized in liver; dose reduction may be required

Monitor

CBC

Discontinue if WBC <3000/mm³ or platelets <150,000/mm³

Other Indications & Uses

Malignant lymphomas (lymphosarcoma, giant follicular lymphoma)

Off-label: Uveitis & meningoencephalitis associeted with Behcet's disease; other NHL; idiopathic membranous nephropathy; RA

Pediatric

Dosage Forms & Strengths

tablet

  • 2 mg

Chronic Lymphatic (Lymphocytic) Leukemia (Off-label)

Safety and efficacy not established, but has been used unlabeled

0.1-0.2 mg/kg PO qDay

Geriatric

Chronic Lymphatic (Lymphocytic) Leukemia
0.1 mg/kg/day for 3-6 weeks or  
0.4 mg/kg (increased by 0.1 mg/kg/dose until response/toxicity observed) biweekly or
0.4 mg/kg (increased by 0.1 mg/kg/dose until response observed) monthly or
0.03-0.1 mg/kg/day continuously
Reduce initial dose if administered within 4 weeks after a full course of radiation/myelosuppressive therapy or patients with bone marrow disease
Not to exceed 0.1 mg/kg/day if bone marrow infiltrated with lymphocytes

Hodgkin's Lymphoma
0.2 mg/kg/day for 3-6 weeks or 
0.4 mg/kg (increased by 0.1 mg/kg/dose until response/toxicity observed) biweekly or
0.4 mg/kg (increased by 0.1 mg/kg/dose until response or toxicity observed) monthly or
0.03-0.1 mg/kg/day continuously
Reduce initial dose if administered within 4 weeks after a full course of radiation/myelosuppressive therapy or patients with bone marrow disease
Not to exceed 0.1 mg/kg/day if bone marrow infiltrated with lymphocytes

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Leukeran 5 only for the indication prescribed.