Leukeran 5

Chlorambucil 5mg

Pharmacology
Mechanism of Action
Alkylating agent of nitrogen mustard family, crosslinks DNA and interferes with DNA replication and RNA transcription; cell cycle nonspecific

Absorption
Bioavailability: 70-80%
Peak Plasma Time: 1 hr

Distribution
Protein Bound: 99%
Vd: 0.3 L/kg

Metabolism
Liver
Metabolites: phenylacetic acid mustard

Elimination
Half-Life: 1.5 hr (chlorambucil); 2.5 hr (phenylacetic acid mustard)
Clearance: 492 ±160 ng/mL (chlorambucil); 306±73 ng/mL (phenylacetic acid mustard)
Excretion: Urine (20-60% metabolites)
Dialyzable: No

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Leukeran 5 only for the indication prescribed.