Marcofen 300 mg

Ibuprofen 300 mg.

Pharmacology

Mechanism of Action

Inhibits synthesis of prostaglandins in body tissues by inhibiting at least 2 cyclo-oxygenase (COX) isoenzymes, COX-1 and COX-2

May inhibit chemotaxis, alter lymphocyte activity, decrease proinflammatory cytokine activity, and inhibit neutrophil aggregation; these effects may contribute to anti-inflammatory activity

Absorption

Rapidly absorbed (85%)

Bioavailability: 80-100%

Onset: 30-60 min

Duration: 4-6 hr

Peak plasma time (adults)

  • Conventional tablet: 120 min
  • Chewable tablet: 62 min
  • Oral suspension: 47 min

Peak plasma time (febrile children)

  • Chewable tablet: 86 min
  • Oral suspension: 58 min

Peak plasma concentration

  • Conventional tablet: 20 mcg/mL
  • Chewable tablet: 15 mcg/mL
  • Oral suspension: 19 mcg/mL

Distribution

Protein bound: 90-99%; concentrations >20 mcg/mL

Vd: 0.12 L/kg (adults); 0.164 L/kg (children)

Metabolism

Rapidly metabolized in liver (primarily by CYP2C9; CYP2C19 substrate) via oxidation to inactive metabolites

Metabolites

  • Metabolite A: (+)-2-[4'-(2-hydroxy-2-methylpropyl) phenyl] propionic acid
  • Metabolite B: (+)-2-[4'-(2-carboxypropyl) phenyl] propionic acid

Elimination

Half-life: 2-4 hr (adults); 1.6 hr (children 3 mon to 1 year; 35-51 hr (day 3), 20-33 hr (day 5)

Excretion: Urine (50-60%; <10% unchanged); remainder in feces within 24 hr

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Marcofen 300 mg only for the indication prescribed.

Verified References
  • FDA Dec 17, 2017
  • CDC Dec 17, 2017
  • Mayo Clinic Dec 17, 2017
  • Drugs.com accessed Dec 17, 2017
  • Medscape accessed Dec 17, 2017
  • Epocrates accessed Dec 17, 2017
  • Webmd accessed Dec 17, 2017