Norpace 100 mg

Disopyramide 100 mg

Dosing & Uses
Adult

Dosage Forms & Strengths

capsule

  • 100 mg
  • 150 mg

capsule, controlled-release

  • 100 mg
  • 150 mg

Ventricular Arrythmias

>50 kg

  • Immediate-release: 150 mg PO q6hr
  • Controlled-release: 300 mg q12hr
  • Range: 400-800 mg/day

<50 kg

  • Immediate-release: 100 mg PO q6hr
  • Controlled-release: 200 mg PO q12hr

Rapid Control of Ventricular Arrythmias

>50 kg

  • Immediate-release: 300 mg PO initially, THEN 150-300 mg q6hr
  • If no response within 6 hours, give 200 mg PO q6hr, may increase to 250-300 mg q6hr if no response in 48 hours

<50 kg

  • Immediate-release: 200 mg PO initially, THEN 150-300 mg q6hr
  • CR should not be used initially for rapid control

Renal Impairment

Immediate-release

  • CrCl >40 mL/min: 100 mg PO q6hr
  • CrCl 30-40 mL/min: 100 mg PO q8hr
  • CrCl 15-30 mL/min: 100 mg PO q12hr
  • CrCl <15 mL/min: 100 mg PO qDay

Controlled-release

  • CrCl >40 mL/min: 200 mg q12hr
  • CrCl ≤40 mL/min: CR not recommended

Hepatic Impairment

Immediate-release: 100 mg PO q6hr OR

Controlled-release: 200 mg q12hr

Monitoring

Therapeutic range 2-4 mcg/mL, toxic range >9 mcg/mL

Pediatric

Dosage Forms & Strengths

capsule

  • 100 mg
  • 150 mg

capsule, extended-release

  • 100 mg
  • 150 mg

Ventricular Arrhythmias (Off-label)

<1 year old: 10-30 mg/kg/day divided q6hr PO 

1-4 years old: 10-20 mg/kg/day divided q6hr PO

4-12 years old: 10-15 mg/kg/day divided q6hr PO

12-18 years old: 6-15 mg/kg/day divided q6hr PO

Geriatric

Avoid; potent negative inotrope that may induce heart failure in older adults; nonanticholinergic antiarrhythmic drugs preferred (Beers criteria)
Dose selection in the elderly should be cautious, usually starting at the low end of the dosing range
CNS anticholinergic effects such as confusion, agitation and hallucinations can be intolerable and may lead to discontinuation

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Norpace 100 mg only for the indication prescribed.

Verified References
  • FDA Jan 31, 2018
  • CDC Jan 31, 2018
  • Mayo Clinic Jan 31, 2018
  • Drugs.com accessed Jan 31, 2018
  • Medscape accessed Jan 31, 2018
  • Epocrates accessed Jan 31, 2018
  • Webmd accessed Jan 31, 2018