Norpace 100 mg

Disopyramide 100 mg

Pharmacology
Mechanism of action
Direct membrane depressant that decreases conduction velocity, prolongs refractoriness, decreases automaticity and reduces repolarization abnormalities

Absorption
Bioavailability: 60-83%
Peak Plasma Time: 1-2.5 hr (immediate-release); 4-7 hr (controlled-release)
Onset: 30 min-3.5 hr
Duration: 1.5-8.5 hr

Distribution
Protein Bound: 20-60%
Vd: 0.8-2 L/kg

Metabolism
Metabolised by CYP3A4 in liver (45%) and intestinal wall (16%)
Metabolites: N-monodealkylated metabolite (active met w/ less antiarrhythmic activity, but greater anticholinergic activity)

Elimination
Half-Life: 4-10 hr (parent drug); 12.9 hr (metabolite: N-monodealkylated metabolite)
Total Body Clearance: 1-2 mL/min/kg
Renal Clearance: 107 mL/min
Excretion: urine (40-80%); feces (10-15%)
Dialyzable: Yes, maintenance dose after dialysis is recommended

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Norpace 100 mg only for the indication prescribed.

Verified References
  • FDA Jan 31, 2018
  • CDC Jan 31, 2018
  • Mayo Clinic Jan 31, 2018
  • Drugs.com accessed Jan 31, 2018
  • Medscape accessed Jan 31, 2018
  • Epocrates accessed Jan 31, 2018
  • Webmd accessed Jan 31, 2018