Norpace 100 mg

Disopyramide 100 mg

Warnings
Black Box Warnings
National Heart, Lung, and Blood Institute's Cardiac Arrhythmia Suppression Trial (CAST): Excessive mortality or nonfatal cardiac arrest (7.7%) shown with encainide or flecainide compared with placebo (3%)
CAST was a long-term, multicenter, randomized, double-blind study in patients with asymptomatic non-life-threatening ventricular arrhythmias who had a myocardial infarction (MI) >6 days but <2 yr previously
Average duration of treatment with encainide or flecainide in CAST was 10 months
Applicability of CAST results to other populations (eg, patients without recent MI) is uncertain
Reserve use of Class IC antiarrhythmics for life-threatening ventricular arrhythmias: Considering the known proarrhythmic properties of disopyramide & lack of evidence of improved survival for any antiarrhythmic drug in patients without life-threatening arrhythmias, disopyramide use, as well as other antiarrhythmic agents, should be reserved for patients with life-threatening ventricular arrhythmias

Contraindications
Hypersensitivity
Cardiogenic shock, preexisting second or third degree heart block, congenital QT syndrome, sick sinus syndrome

Cautions
CHF, ECG abnormalities, electrolyte abnormalities (hypo/hyper K), glaucoma, hypoglycemia, myasthenia gravis, sick sinus syndrome, BPH/urinary retention, need normal potassium prior to use, hypotension, cardiac myopathies, heart failure, prostatic enlargement, Wolff-Parkinson-White syndrome, bundle branch block, hepatic/renal impairment
Hypotension may occur
May cause QTc prolongation and subsequent torsade de pointes
Can both precipitate and exacerbate HF due to marked myocardial depressant effects in HF

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Norpace 100 mg only for the indication prescribed.

Verified References
  • FDA Jan 31, 2018
  • CDC Jan 31, 2018
  • Mayo Clinic Jan 31, 2018
  • Drugs.com accessed Jan 31, 2018
  • Medscape accessed Jan 31, 2018
  • Epocrates accessed Jan 31, 2018
  • Webmd accessed Jan 31, 2018