Psychodal 1mg Drops

Risperidone 1mg

Pharmacology
Mechanism of Action
Improves negative symptoms of psychoses and reduces incidence of EPS
Has high affinity for serotonin type 2 (5-HT2) receptors; binds to dopamine D2 receptors with 20 times lower affinity than that for 5-HT2 receptors; antagonizes alpha1-adrenergic, alpha2-adrenergic, and histaminergic receptors; has moderate affinity for serotonin type 1 (5-HT1C, 5-HT1D, 5-HT1A) receptors; has weak affinity for dopamine D1 receptors; has no affinity for muscarinic, beta1-adrenergic, and beta2-adrenergic receptors

Absorption
Bioavailability: 70%
Peak plasma time: Extensive metabolizers, 3 hr; poor metabolizers, 17 hr

Distribution
Protein bound: Risperidone, 90%; metabolite, 77%
Vd: 1-2 L/kg

Metabolism
Metabolized in liver by CYP2D6
Metabolite: 9-hydroxyrisperidone (paliperidone)

Elimination
Half-life: Extensive metabolizers, 3 hr (parent and metabolite combined); poor metabolizers, 20 hr (parent and metabolite combined); prolonged in renal impairment; free fraction increase in hepatic disease
Excretion: Urine (70%), feces (14%)

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Psychodal 1mg Drops only for the indication prescribed.