Sedopram 20 mg

Citalopram 20 mg

Dosing & Uses
Adult

Dosage Forms & Strengths

tablet

  • 10 mg
  • 20 mg
  • 40 mg

oral solution

  • 10 mg/5 mL

Depression

Depression in patients whose diagnosis corresponds most closely to the DSM-III and DSM-III-R category of major depressive disorder

Initial dose: 20 mg PO qDay

If needed, may increase to 40 mg/day after at least 1 week

Doses above 40 mg/day are not recommended, because of risk for QT prolongation without additional benefit for treating depression

Dosing Modifications

Poor CYP2C19 metabolizers or coadministration with CYP2C19 inhibitors (eg, cimetidine, fluconazole, omeprazole): Do not exceed 20 mg/day

Hepatic impairment decreases clearance and therefore increases risk of QT prolongation; do not exceed 20 mg/day

MAO inhibitors

  • Not for administration within 14 days of administering a MAO inhibitor

Linezolid or Methylene Blue Therapy

  • Not for administration to patients that are receiving linezolid or IV methylene blue; consider other forms of therapy; if therapy required and benefits outweigh risks discontinue citalopram therapy, administer linezolid or methylene blue and monitor for serotonin syndrome for 2 weeks or 24 hr after last dose of linezolid or methylene blue

Renal impairment

  • Mild to moderate renal impairment: No dosage adjustment required
  • Severe renal impairment (CrCl <20 mL/min): Not studied; use with caution

Alcoholism (Off-label)

20-40 mg PO qDay

Binge-eating Disorder (Off-label)

20-60 PO qDay

Generalized Anxiety Disorder (Off-label)

Initial: 10 mg PO qDay; may titrate to 40 mg/day

Panic Disorder (Off-label)

20 mg PO qDay initially; after 1 week, may increase to 40 mg/day if warranted

Not to exceed 40 mg/day because of increased risk for QT prolongation

Hot Flashes (Off-label)

Initial: 10 mg PO qDay; may increase to 20 mg/day after 1 week

Obsessive-Compulsive Disorder (Off-label)

Initial: 20 mg PO qDay; may titrate to 40-60 mg/day; improvement may be seen 4-6 weeks after initiating therapy

Premenstrual Dysphoric Disorder (Off-label)

5 mg PO on the estimated day of ovulation; increase dose by 5 mg each day thereafter to maximum 30 mg; continue thereafter until menstruation begins; decrease dose to 20 mg on the first day of menstruation; the next day, decrease to 10 mg; stop the treatment from day 3 until ovulation begins

Pediatric

Dosage Forms & Strengths

tablet

  • 10 mg
  • 20 mg
  • 40 mg

oral solution

  • 10 mg/5 mL

Depression (Off-label)

<12 years

  • 10 mg PO qDay; may increase by 5 mg/day every 2 weeks  to 40 mg PO qDay; doses >40 mg not recommended (may increase risk of QT prolongation)

≥12 years

  • 20 mg PO qDay; may increase by 10 mg/day every 2 weeks  to 40 mg PO qDay; doses >40 mg not recommended (may increase risk of QT prolongation)

Impulsive Aggresive Behavior (Off-label)

10 mg PO qDay; titrate by 10 mg/week, as tolerated to maximum 40 mg/day

Geriatric

Depression
>60 years: Do not exceed 20 mg PO qDay

Dosing Considerations
-The elderly are more prone to SSRI/SNRI-induced hyponatremia and risk for QT prolongation

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Sedopram 20 mg only for the indication prescribed.