Vasopine 5

Amlodipine besylate 5mg

Pharmacology
Mechanism of Action
Inhibits transmembrane influx of extracellular calcium ions across membranes of myocardial cells and vascular smooth muscle cells without changing serum calcium concentrations; this inhibits cardiac and vascular smooth muscle contraction, thereby dilating main coronary and systemic arteries
Increases myocardial oxygen delivery in patients with vasospastic angina

Absorption
Bioavailability: 64-90%
Onset: 24-96 hr
Duration: 24 hr (antihypertensive effect)
Peak plasma time: 6-12 hr

Distribution
Protein bound: 93-98%
Vd: 21 L/kg

Metabolism
Extensively metabolized in liver by CYP3A4
Metabolites: Pyridine analogue (inactive)

Elimination
Half-life: 30-50 hr
Excretion: Urine (70%)

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Vasopine 5 only for the indication prescribed.